Antidepressants are medications with multiple uses for conditions such as chronic pain, traumatic psychological illnesses, anxiety and depression. They can be prescribed for workers to assist with recovery and return to work.

Some typical side effects of antidepressants include dry mouth, weight gain and lack of sex drive. On occasions they may also cause drowsiness. Caution is required for safety-sensitive positions.

Antidepressants can be divided into five major categories: selective serotonin reuptake inhibitors (SSRIs), serotonin–norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs) and atypical antidepressants. TCAs and MAOIs are generally generally prescribed less frequently because of the incidence of side effects.


Depression (major depressive disorder), Mayo Clinic
Depression – Medicines To Help You, U.S. Food and Drug Administration

E-News Sign-up